• br Disclosure statement br Acknowledgements The work was

  2025-01-04

  

  Disclosure statement Acknowledgements The work was supported by the National Science Foundation of China (Nos. 81273526, 81473268) and Natural Science Foundation of Colleges and Universities (Nos. KJ2017A197). What is already known What this article adds Introduction Sevoflurane is o

• The renin angiotensin system RAS

  2025-01-04

  

  The renin-angiotensin system (RAS) is a hormonal system which plays a role in the regulation of blood pressure and body fluid RI-1 [14]. The main bioactive peptide of RAS is angiotensin II (Ang II) whose biological functions are interposed through angiotensin type 1 receptor (AT1R) and angiotensin

• Breast Cancer Although androgens have been considered

  2025-01-03

  

  Breast Cancer: Although androgens have been considered to be a risk factor in prostate cancer they have been recommended to treat breast cancers. Even before the discovery of SERMs and aromatase inhibitors, steroidal androgens such as medroxyprogesterone and fluoxymesterone were used to treat breast

• Hyperactivity of the hypothalamus pituitary

  2025-01-03

  

  Hyperactivity of the hypothalamus-pituitary-adrenal (HPA) axis, which is well described in MDD (Pariante and Lightman, 2008, Marques et al., 2009), is also observed in AD and results in increased glucocorticoid (GC, cortisol in primates) levels in blood and CSF (Davis et al., 1986, Martignoni et al.

• Pathogen infected macrophages release exosomes associating w

  2025-01-03

  

  Pathogen-infected HIV medication release exosomes associating with pathogen-associated molecular patterns (PAMPs) such as LPS and lipoprotein derived from microorganisms [29,30]. Exosomes released by bacterially infected, but not uninfected, macrophages stimulate macrophages to release inflammatory

• With regard to the correlation

  2025-01-03

  

  With regard to the correlation between -rearrangements and thromboembolic events, Zer et al. reported a VTE rate of 36% in a cohort of 98 patients with ALK-positive NSCLC. Of note, VTE was also associated with shorter overall survival (HR: 5.71, =0.01) . Only few others have investigated NSCLC drive

• 99026 To further clarify the vascular cell

  2025-01-03

  

  To further clarify the vascular cell types expressing AR subtypes, double immunofluorescence staining for ARs and vascular endothelial 99026 or vascular smooth muscles was performed. As shown in Fig. 3, Fig. 4, overlay images show the expression of all ARs subtypes that we examined in vascular endot

• Here we have used transcriptome analysis of

  2025-01-03

  

  Here, we have used transcriptome analysis of primary neonatal rat cardiomyocytes treated with either the ETR agonist endothelin-1 or the α1-AR agonist phenylephrine to assess differences in their respective signalling networks, and further probed these differences using a panel of fluorescent resona

• Our analysis has devoted limited attention to

  2025-01-03

  

  Our analysis has devoted limited attention to the standard corporate tax scheme with deductibility for interest payments that is in place in most countries. A conventional corporate tax scheme offers partial deduction of capital costs, and can be interpreted as a change in the degree of capital cost

• br Conflicts of interest br Acknowledgments

  2025-01-02

  

  Conflicts of interest Acknowledgments The authors acknowledge National Institute for Medical Research Development (NIMAD) project no. 940943 and National Research Institute for Science Policy (NRISP) no. 1456 for financial support of this work. AM appreciates National Institute for Genetic Eng

• br Acknowledgements br Introduction Double stranded DNA brea

  2025-01-02

  

  Acknowledgements Introduction Double-stranded DNA breaks (DSBs) are among the most deleterious DNA lesions that threaten genomic integrity. DSBs are generated not only by exogenous DNA-damaging agents but also by normal cellular processes such as V(D)J recombination, meiosis, and DNA replicati

• Since E was shown to affect the expression

  2025-01-02

  

  Since E2 was shown to affect the expression of Hsps, the transcript expression levels of another 11 Hsps were also evaluated by real-time PCR with their specific primers. The transcripts of 4 proteins (Hsp10, Hsp56, Hsp70a and Hsp110) were significantly up-regulated, but that of Hsp47 was significan

• The reasons why antibiotic treatment may be detrimental

  2025-01-02

  

  The reasons why antibiotic treatment may be detrimental are diverse. First, it may result in disruption of multifaceted microbe–microbe, as well as microbe–host, interactions that are key for the maintenance of homeostasis within this ecosystem. This can lead to the expansion of pathogenic microorga

• Purvalanol B In previous research we determined that

  2024-12-31

  

  In previous research, we determined that blocking mAC during heparin-induced capacitation result in sperm having a lesser oxygen consumption, suggesting that cAMP produced by this enzyme would be linked to mitochondrial activity and, therefore, with the regulation of sperm metabolism (Fernández and

• If overexpression of ADK is sufficient to induce

  2024-12-31

  

  If overexpression of ADK is sufficient to induce spontaneous seizures, then reduction of ADK in engineered mice should prevent epileptogenesis. The generation of mice with moderately reduced levels of ADK in brain rather than complete ADK deficiency seems to be essential, since several lines of evid

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